Provide the following information for the key
personnel and other significant contributors in the order listed on Form Page
Charles D. Smith
Robert P. and Mildred Moores Professor in Alzheimer's Research
eRA COMMONS USER NAME
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
FIELD OF STUDY
A. Positions and Honors
1979-1980 Intern, Department of Internal
1980-1981 Resident, Department of Internal
1981-1984 Resident, Department of
1983-1984 Instructor, Department of
1986 Board Certification, American Board of Psychiatry & Neurology
1984-1987 Assistant Professor, Department
of Neurology, University of
1985-1987 Assistant Clinical Professor,
Department of Neurology,
1989-1994 Recipient, Clinical Investigator Development Award (CIDA), NIH/NINCDS
1989-1994 Assistant Professor, Department
1994 Certification in Magnetic Resonance Imaging, American Society of Neuroimaging
1993- Present Graduate Faculty, Center for Biomedical Engineering,
1994 Certification in Computed Axial Tomography, American Society of Neuroimaging
1994-2001 Associate Professor, Department
1995- Present Director, Memory Disorders Clinic & Clinical Core B, Alzheimer’s
Disease Research Center (ADRC) &
1998-2001 Associate Professor of Anatomy&
2001-Present Professor of Neurology,
2001-Present Professor of Anatomy & Neurobiology,
2007-Present Director, Magnetic Resonance Imaging and
1972-1974 McMullen Scholar,
1985- Present International Society of Magnetic Resonance in Medicine
1985- Present Cornell Society of Engineers
1989- Present American Society of Neuroimaging
1989- Present Faculty, Magnetic Resonance Imaging and
1990- 2001 Fellow, Stroke Council, American Heart Association
1998- Present American Neurological Association
B. Selected peer-reviewed publications (in chronological order) (Publications selected from 71peer-reviewed publications)
1. Smith CD, Carney JM, Starke-Reed PE, Oliver CN Stadtmann ER, Floyd RA, Markesbery WR. Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer's disease. PNAS 1991; 88:10540-10543.
2. Smith CD, Carney JM, Tatsumo T, Stadtmann ER, Floyd RA, Markesbery WR. Protein oxidation in aging brain. Ann NYAcad Sci 1992; 663:110-119.
CD, Gallenstein LG,
4. Smith CD, Ain K.A. Human brain metabolism in hypothyroidism studied with 31P magnetic-resonance spectroscopy. Lancet1995; 345: 619-620.
5. Smith CD, Pettigrew LC, Avison MJ, Kirsch JE, Tinkhtman AJ, Schmitt FA, Wermeling DP, Wekstein DR, Markesberry WR. Frontal lobe phosphorus metabolism and neuropsychologic function imaging and Alzheimer’s disease. Ann Neurol 1995; 38:584-591.
6. Smith CD, Landrum W, Carney JM, Landfield PW, Avison MJ. brain creatine kinase forward flux by magnetization transfer: effect of age in Fisher 344 rats. Neurobiol Aging 1997; 18(6):617-622.
7. Aksenov MY, Aksenova MV, Payne RM, Smith CD, Markesbery WR, Carney JM. The expression of creatine kinaseiso enzymes in neocortex of patients with neurodegenerative disorders: Alzheimer's and Pick's disease. Exp Neurol 1997; 146:458-65.
8. Smith CD, Malcein M, Meurer K, Schmitt FA, Markesbery WA, Pettigrew LC. MRI Temporal Lobe Volumetric Measures and Neuropsychologic Function in Alzheimer’s Disease: J Neuroimaging 1999; 9:2-9.
9. Smith CD, Trevathan ER, Zhang M, Andersen AH, Avison MJ. Functional MRI evidence for task-specific activation of developmentally abnormal visual association cortex. Ann Neurol 1999; 45:515-518.
10. Smith CD, Andersen AH, Kryscio RJ, Schmitt FA, Blonder LX, Kindy MS, Avison MJ. Altered brain activation in normal subjects at risk for Alzheimer's disease. Neurology 1999; 53:1391-1396.
FA, Davis DG,
15. Wackerbarth SB, Johnson MMS, Markesbery WR, Smith CD. Urban-rural differences in a memory disorders clinical population. J. Amer. Geriatr Soc 2001; 49:647-650.
16. Smith CD. Serial MRI findings in a case of primary lateral sclerosis. Neurology 2002; 57:647-649.
17. Smith CD, Andersen AH, Kryscio RJ, Schmitt FA, Kindy MS, Blonder LX, Avison MJ. Women at high risk for Alzheimer's disease show increased parietal activation in a letter fluency task. Neurology 2002; 58:1197-1202.
KM, Mortimer JA, Smith CD, Markesbery WR,
19. Gaugler JE, Mendiondo M, Smith CD, Schmitt FA. Secondary dementia care giving and its consequences. Am J Alzheimer's Disease 2003; 18: 300-308.
20. Nath A, Hall E, Tuzova M, Dobbs M, Jons M, Anderson C, Woodward J, Guo Z, Fu W, Kryscio R, Wekstein D, Smith CD, Markesbery WR, Mattson MP. Autoantibodies to amyloid beta-peptide (Abeta) are increased in Alzheimer's disease patients and Abeta antibodies can enhance Abeta neurotoxicity: implications for disease pathogenesis and vaccine development. Neuromolecular Med2003; 3:29-39.
21. Gaugler JE, Anderson KA, Leach, CR, Smith, CD, Schmitt, FA., Mendiondo, M. The emotional ramifications of unmet need in dementia caregiving. Am JAD 2004; 19:369-379.
CD, Walton A,
23. Slevin JT, Gerhardt GA, Smith CD, Gash DM, Kryscio R, Young B. Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophicfactor. J Neurosurg 2005; 102:216-22.
24. Smith CD, Kryscio RJ, Schmitt FA, Lovell MA, Blonder LX, Rayens WS, Andersen AH. Longitudinal functional alterations in asymptomatic women at risk for Alzheimer's disease. J Neuroimaging 2005;15:271-277.
H, Slevin JT, Gash DA,
26. Gold BT, Balota DA, Jones SJ, Powell DK, Smith CD, Andersen AH. Dissociation of automatic and strategic lexical-semantics: functional magnetic resonance imaging evidence for differing roles of multiple frontotemporal regions. J Neurosci 2006; 26: 6523-6532.
27. Markesbery WR, Schmitt FA, Kryscio RJ, Davis DG, Smith CD, Wekstein DR. Neuropathologic substrate of mild cognitive impairment. Arch Neurol2006; 63: 38-46.
28. Slevin JT, Gash DM, Smith CD, Gerhardt GA, Kryscio R, Chebrolu H, Walton A, Wagner R, Young AB. Unilateral intraputaminal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year each of treatment and withdrawal. Neurosurg Focus 2006; 20: E1.
29. Smith CD, Chebrolu H, Wekstein DR, Schmitt FA, Markesbery WR. Age and gender effects on human brain anatomy: A voxel-based morphometric study in healthy elderly. Neurobiol Aging 2006.
31. Mehta SG, Watts CDJ, Adamson J, Hutton M, G. Umberger G, Xiong S, Ramdeen S, Lovell M, Kimonis VE, Smith CD. APOE is a Potential Modifier Gene in an Autosomal Dominant Form of Frontotemporal Dementia(IBMPFD). Genetics in Medicine 2006 (In Press).
32. Smith CD, ChebroluH, Wekstein DR, Schmitt FA, Jicha GA, Cooper G, Markesbery WR. Brain Structural Alterations Before Mild Cognitive Impairment. Neurology 2006 (In Press).
C. Research Support
NIH/NINDS R01 036660 (PI Smith) 9/30/97-12/31/07
Detection of Pre-symptomatic Alzheimer's Disease by fMRI 3.6calendar
This study seeks to detect functional brain alterations in asymptomatic people with high risk of later developing AD.
NIH/NIA P50 AG005144 (P50 PI Markesbery/ PI Core B/Clinic Smith) 9/30/85-6/30/11
Alzheimer's Disease Center (ADC) 2.4calendar
The clinical core provides diagnostic services, performs clinical trials, and recruits and follows persons with dementia from diagnosis to autopsy.
NIH/NIA P50 AG005144 (PI Markesbery/ Co-PI Smith) 9/30/85-6/39/11
Alzheimer's Disease Center (ADC)
Minority Emphasis Satellite Memory Disorders
This satellite clinic provides diagnostic
services and research subjects from an underserved minority population in
NIH/NIMH R01MH063817 (PI Joseph/ Co-PI Smith) 4/01/03-3/31-07
Neuroimaging of shape similarity in object recognition 0.6calendar
This project seeks to determine the contribution of shape similarity to visual object recognition in healthy humans using functional magnetic resonance imaging.
NIH/NIA U01 AG024904 (Weiner/ Site PI Smith) 9/30/04-9/29/09
Alzheimer's Disease Neuroimaging Initiative (ADNI) 0.6calendar
Longitudinal multi-center study of neuroimaging and related biomarkers in normal subjects and those with mild cognitive impairment and early Alzheimer’s Disease.
M-05411849 (PI Danner/ Co-PI Smith) 7/01/04-6/30/07
Administration on Aging (AOA) 0.0calendar
NIH/NIMH R01MH078228 (Blonder, L., PI, Co-PI Smith) 10/1/06-9/29/11
Neuroimaging Studies of Depression in Parkinson's Disease 0.6calendar
This study uses fMRI methods to elucidate substrates of depression in Parkinson's disease.
NIH/NIA R01AG025159 (PI Smith) 9/15/06-6/30/09
Imaging brain function/structure in pre-symptomatic FTD 1.8calendar
Studies families harboring a known autosomal dominant mutation causing muscular dystrophy, Paget's disease of bone and frontotemporal dementia to determine imaging and psychometric biomarkers for dementia in asymptomatic carriers.
Overlap: There is no scientific overlap in the specific aims or effort overload involved in these grants.