Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person.  DO NOT EXCEED FOUR PAGES.



Charles D. Smith


Robert P. and Mildred Moores Professor in Alzheimer's Research



EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)



(if applicable)



Cornell University, Ithaca, NY  



Electrical Engineering

Cornell University, Ithaca, NY



Electrical Engineering

Tulane University, New Orleans, LA




University of Kentucky, Lexington, KY



Magnetic Resonance

A.      Positions and Honors

Professional Experience

1979-1980       Intern, Department of Internal Medicine, Dartmouth Medical School, Hanover, New Hampshire

1980-1981       Resident, Department of Internal Medicine, Dartmouth Medical School

1981-1984       Resident, Department of Neurology, Dartmouth Medical School

1983-1984       Instructor, Department of Neurology, Dartmouth Medical School

1986                Board Certification, American Board of Psychiatry & Neurology

1984-1987       Assistant Professor, Department of Neurology, University of Wisconsin Medical School

1985-1987       Assistant Clinical Professor, Department of Neurology, Medical College of Wisconsin

                        Milwaukee, Wisconsin (Joint Appt.)

1989-1994       Recipient, Clinical Investigator Development Award (CIDA), NIH/NINCDS

1989-1994       Assistant Professor, Department of Neurology, University of Kentucky, Lexington, Kentucky

1994                Certification in Magnetic Resonance Imaging, American Society of Neuroimaging

1993- Present Graduate Faculty, Center for Biomedical Engineering, University of Kentucky

1994                Certification in Computed Axial Tomography, American Society of Neuroimaging

1994-2001       Associate Professor, Department of Neurology, University of Kentucky

1995- Present Director, Memory Disorders Clinic & Clinical Core B, Alzheimer’s Disease Research Center (ADRC) & Sanders-Brown Center on Aging, University of Kentucky

1998-2001       Associate Professor of Anatomy& Neurobiology, University of Kentucky (Joint Appt.)

2001-Present  Professor of Neurology, University of Kentucky

2001-Present  Professor of Anatomy & Neurobiology, University of Kentucky (Joint Appt.)

2007-Present Director, Magnetic Resonance Imaging and Spectroscopy Center (MRISC), University of                          Kentucky, Lexington, Kentucky

Honors; Affiliations

1972-1974       McMullen Scholar, Cornell University

1978                Tulane Medical School, AOA

1985- Present International Society of Magnetic Resonance in Medicine

1985- Present American Academy of Neurology

1985- Present Cornell Society of Engineers

1989- Present American Society of Neuroimaging

1989- Present Faculty, Magnetic Resonance Imaging and Spectroscopy Center

1990- 2001      Fellow, Stroke Council, American Heart Association

1998- Present American Neurological Association

B.  Selected peer-reviewed publications (in chronological order) (Publications selected from 71peer-reviewed publications)

1.                  Smith CD, Carney JM, Starke-Reed PE, Oliver CN Stadtmann ER, Floyd RA, Markesbery WR.  Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer's disease.  PNAS 1991; 88:10540-10543.

2.                  Smith CD, Carney JM, Tatsumo T, Stadtmann ER, Floyd RA, Markesbery WR.  Protein oxidation in aging brain.  Ann NYAcad Sci 1992; 663:110-119.

3.                  Smith CD, Gallenstein LG, Layton WJ, Kryscio RJ, Markesbery WR.  31P Magnetic resonance spectroscopy in Alzheimer's and Pick's Disease.  Neurobiol Aging 1993; 14:85-92.

4.                  Smith CD, Ain K.A. Human brain metabolism in hypothyroidism studied with 31P magnetic-resonance spectroscopy.  Lancet1995; 345: 619-620.

5.                  Smith CD, Pettigrew LC, Avison MJ, Kirsch JE, Tinkhtman AJ, Schmitt FA, Wermeling DP, Wekstein DR, Markesberry WR.  Frontal lobe phosphorus metabolism and neuropsychologic function imaging and Alzheimer’s disease.  Ann Neurol 1995; 38:584-591.

6.                  Smith CD, Landrum W, Carney JM, Landfield PW, Avison MJ.  brain creatine kinase forward flux by magnetization transfer: effect of age in Fisher 344 rats.  Neurobiol Aging 1997; 18(6):617-622.

7.                  Aksenov MY, Aksenova MV, Payne RM, Smith CD, Markesbery WR, Carney JM.  The expression of creatine kinaseiso enzymes in neocortex of patients with neurodegenerative disorders: Alzheimer's and Pick's disease.  Exp Neurol 1997; 146:458-65.

8.                  Smith CD, Malcein M, Meurer K, Schmitt FA, Markesbery WA, Pettigrew LC.  MRI Temporal Lobe Volumetric Measures and Neuropsychologic Function in Alzheimer’s Disease: J Neuroimaging 1999; 9:2-9.

9.                  Smith CD, Trevathan ER, Zhang M, Andersen AH, Avison MJ.  Functional MRI evidence for task-specific activation of developmentally abnormal visual association cortex.  Ann Neurol 1999; 45:515-518.

10.              Smith CD, Andersen AH, Kryscio RJ, Schmitt FA, Blonder LX, Kindy MS, Avison MJ.  Altered brain activation in normal subjects at risk for Alzheimer's disease.  Neurology 1999; 53:1391-1396.

11.              Smith CD, Snowdon DA, Markesbery WR.  Periventricular white matter hyperintensities on MRI: correlation with neuropathologic findings.  J Neuroimaging 2000; 10:13-16.

12.              Smith CD, Snowdon DA, Wang H, Markesbery WR.  White matter volumes and periventricular white matter hyperintensities imaging and dementia.  Neurology2000; 54:838-842.

13.              Snowdon DA, Tully CL, Smith CD, Riley KP, Markesbery WR.  Serum folate and the severity of atrophy of the neocortex in Alzheimer's disease: Findings from the Nun study.  J Clin Nutrition 2000; 71:993-998.

14.              Schmitt FA, Davis DG, Wekstein DR, Smith CD, Ashford JW, Markesbery WR.  “Preclinical" AD revisited: neuropathology of cognitively normal older adults.  Neurology 2000; 55:370-376.

15.              Wackerbarth SB, Johnson MMS, Markesbery WR, Smith CD.  Urban-rural differences in a memory disorders clinical population.  J. Amer. Geriatr Soc 2001; 49:647-650.

16.              Smith CD.  Serial MRI findings in a case of primary lateral sclerosis.  Neurology 2002; 57:647-649.

17.              Smith CD, Andersen AH, Kryscio RJ, Schmitt FA, Kindy MS, Blonder LX, Avison MJ.  Women at high risk for Alzheimer's disease show increased parietal activation in a letter fluency task.  Neurology 2002; 58:1197-1202.

18.              Gosche KM, Mortimer JA, Smith CD, Markesbery WR, Snowdon DA.  Hippocampal volume as an index of Alzheimer neuropathology: Findings from the Nun study.  Neurology 2002; 58: 1476-1482.

19.              Gaugler JE, Mendiondo M, Smith CD, Schmitt FA.  Secondary dementia care giving and its consequences.  Am J Alzheimer's Disease 2003; 18: 300-308.

20.              Nath A, Hall E, Tuzova M, Dobbs M, Jons M, Anderson C, Woodward J, Guo Z, Fu W, Kryscio R, Wekstein D, Smith CD, Markesbery WR, Mattson MP.  Autoantibodies to amyloid beta-peptide (Abeta) are increased in Alzheimer's disease patients and Abeta antibodies can enhance Abeta neurotoxicity: implications for disease pathogenesis and vaccine development.  Neuromolecular Med2003; 3:29-39.

21.              Gaugler JE, Anderson KA, Leach, CR, Smith, CD, Schmitt, FA., Mendiondo, M.  The emotional ramifications of unmet need in dementia caregiving.  Am JAD 2004; 19:369-379.

22.              Smith CD, Walton A, Loveland AD, Umberger GH, Kryscio RJ, Gash DM. Memories that last in old age: motor skill learning and memory preservation.  Neurobiol Aging.  2005;26:883-890.

23.              Slevin JT, Gerhardt GA, Smith CD, Gash DM, Kryscio R, Young B. Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophicfactor.  J Neurosurg 2005; 102:216-22.

24.              Smith CD, Kryscio RJ, Schmitt FA, Lovell MA, Blonder LX, Rayens WS, Andersen AH.  Longitudinal functional alterations in asymptomatic women at risk for Alzheimer's disease.  J Neuroimaging 2005;15:271-277.

25.              Chebrolu H, Slevin JT, Gash DA, Gerhardt GA, Young B, Given CA, Smith CD.  MRI volumetric and intensity analysis of the cerebellum in Parkinson's disease patients infused with glial-derived neurotrophic factor (GDNF).  Exp Neurol 2006; 198: 450-456.

26.              Gold BT, Balota DA, Jones SJ, Powell DK, Smith CD, Andersen AH.  Dissociation of automatic and strategic lexical-semantics: functional magnetic resonance imaging evidence for differing roles of multiple frontotemporal regions.  J Neurosci 2006; 26: 6523-6532.

27.              Markesbery WR, Schmitt FA, Kryscio RJ, Davis DG, Smith CD, Wekstein DR.  Neuropathologic substrate of mild cognitive impairment.  Arch Neurol2006; 63: 38-46.

28.              Slevin JT, Gash DM, Smith CD, Gerhardt GA, Kryscio R, Chebrolu H, Walton A, Wagner R, Young AB.  Unilateral intraputaminal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year each of treatment and withdrawal.  Neurosurg Focus  2006; 20: E1.

29.              Smith CD, Chebrolu H, Wekstein DR, Schmitt FA, Markesbery WR.  Age and gender effects on human brain anatomy: A voxel-based morphometric study in healthy elderly.  Neurobiol Aging 2006.

30.              Smith CD, Wekstein DR, Markesbery WR, Frye CA. 3alpha,5alpha-THP: a potential plasma neurosteroid biomarker in Alzheimer's disease and perhaps non-Alzheimer's dementia.  Psychopharmacology(Berl) 2006;186: 481-485.

31. Mehta SG, Watts CDJ, Adamson J, Hutton M, G. Umberger G, Xiong S, Ramdeen S, Lovell M, Kimonis VE,       Smith CD.  APOE is a Potential Modifier Gene in an Autosomal Dominant Form of Frontotemporal       Dementia(IBMPFD).  Genetics in Medicine 2006 (In Press).

32. Smith CD, ChebroluH, Wekstein DR, Schmitt FA, Jicha GA, Cooper G, Markesbery WR.  Brain Structural       Alterations Before Mild Cognitive Impairment.  Neurology 2006 (In Press).



C.  Research Support

Ongoing Research Support

NIH/NINDS R01 036660 (PI Smith)                                                             9/30/97-12/31/07

Detection of Pre-symptomatic Alzheimer's Disease by fMRI                                                3.6calendar

This study seeks to detect functional brain alterations in asymptomatic people with high risk of later developing AD.

NIH/NIA P50 AG005144  (P50 PI Markesbery/ PI Core B/Clinic Smith)    9/30/85-6/30/11

Alzheimer's Disease Center (ADC)                                                                           2.4calendar

The clinical core provides diagnostic services, performs clinical trials, and recruits and follows persons with dementia from diagnosis to autopsy.

NIH/NIA P50 AG005144 (PI Markesbery/ Co-PI Smith)                            9/30/85-6/39/11

Alzheimer's Disease Center (ADC)

Minority Emphasis Satellite Memory Disorders Clinic (Kentucky Clinic North)         1.2calendar

This satellite clinic provides diagnostic services and research subjects from an underserved minority population in Lexington, Kentucky.

NIH/NIMH R01MH063817 (PI Joseph/ Co-PI Smith)                                  4/01/03-3/31-07          

Neuroimaging of shape similarity in object recognition                                              0.6calendar

This project seeks to determine the contribution of shape similarity to visual object recognition in healthy humans using functional magnetic resonance imaging.

NIH/NIA U01 AG024904 (Weiner/ Site PI Smith)                                        9/30/04-9/29/09          

Alzheimer's Disease Neuroimaging Initiative (ADNI)                                                  0.6calendar

Longitudinal multi-center study of neuroimaging and related biomarkers in normal subjects and those with mild cognitive impairment and early Alzheimer’s Disease.

M-05411849 (PI Danner/ Co-PI Smith)                                                        7/01/04-6/30/07

Administration on Aging (AOA)                                                                                   0.0calendar

Dementia Outreach Lexington: Diagnosis, Treatment and Services for African Americans

NIH/NIMH R01MH078228 (Blonder, L., PI, Co-PI Smith)                           10/1/06-9/29/11

Neuroimaging Studies of Depression in Parkinson's Disease                                  0.6calendar

This study uses fMRI methods to elucidate substrates of depression in Parkinson's disease.

NIH/NIA  R01AG025159 (PI Smith)                                                              9/15/06-6/30/09

Imaging brain function/structure in pre-symptomatic FTD                                         1.8calendar

Studies families harboring a known autosomal dominant mutation causing muscular dystrophy, Paget's disease of bone and frontotemporal dementia to determine imaging and psychometric biomarkers for dementia in asymptomatic carriers.

Overlap: There is no scientific overlap in the specific aims or effort overload involved in these grants.